DNA damage response

The DNA Damage Response (DDR) has evolved in response to constant exposure of the genome to exogenous and endogenous genotoxins. Consequently, cells deploy a diverse repertoire of mechanisms to maintain genetic integrity involving both the organization of the DNA repair processes themselves and their integration with the cell cycle. Disruption of the DDR is one of the ‘Hallmarks of Cancer’.

The DDR proteins in MOKCa are those documented in Pearl et. al.

COSMIC gene nameNumber of distinct mutations
XPA1
XPC8
XRCC110
XRCC27
XRCC31
XRCC43
XRCC58
XRCC67
XRCC6BP11
DDR

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