MOKCa: Mutations, Oncogenes, Knowledge

MOKCa :: DNA Damage Response :: H

DNA damage response

The DNA Damage Response (DDR) has evolved in response to constant exposure of the genome to exogenous and endogenous genotoxins. Consequently, cells deploy a diverse repertoire of mechanisms to maintain genetic integrity involving both the organization of the DNA repair processes themselves and their integration with the cell cycle. Disruption of the DDR is one of the ‘Hallmarks of Cancer’.

The DDR proteins in MOKCa are those documented in Pearl et. al.

COSMIC gene name	Number of distinct mutations
H2AFX
H2AFZ
H2AFZP2
HELQ	7
HES1	2
HFM1	18
HINFP	8
HLTF	10
HMG1L10
HMGB1	3
HMGB2	1
HUS1	7
HUS1B

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