Members of the protein kinase family are amongst the most commonly mutated genes in human cancer, and both mutated and activated protein kinases have proved to be tractable targets for the development of new anticancer therapies. The MoKCa database (Mutations of Kinases in Cancer) has been developed to structurally and functionally annotate, and where possible predict, the phenotypic consequences of mutations in protein kinases implicated in cancer.


Protein kinases are a group of proteins that add phosphate groups to proteins. There are over 500 documented mammalian protein kinases encoded in the human genome, which together represent the largest family of human enzymes, collectively termed the kinome. They play indispensable roles in numerous cellular, metabolic and signalling pathways, in all cell types.

For further information about Mokca, see our publication in Nucleic Acids Research, available as a free-access PDF.

MoKCa database--mutations of kinases in cancer
Christopher J. Richardson; Qiong Gao; Costas Mitsopoulous; Marketa Zvelebil; Laurence H. Pearl; Frances M. G. Pearl
Nucleic Acids Research 2008; doi: 10.1093/nar/gkn832